Short Communication
- 1 January 1996
- journal article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 377 (4), 259-266
- https://doi.org/10.1515/bchm3.1996.377.4.259
Abstract
Novel angiotensin-I-converting enzyme (ACE) inhibitory activities were detected in synthetic peptides corresponding to sequences of beta-lactoglobulin and alpha-lactalbumin and which are known to possess opioid activity. Using hippuryl-histidyl-leucine as substrate, the tetrapeptides beta-lactorphin (Tyr-Leu-Leu-Phe), alpha-lactorphin (Tyr-Gly-Leu-Phe) and beta-lactotensin (His-Ile-Arg-Leu) were shown to have IC50 values of 171.8, 733.3 and 1153.2 microM, respectively. Related dipeptides also inhibited ACE, with Tyr-Leu being the most potent, having an IC50 value of 122.1 microM.Keywords
This publication has 19 references indexed in Scilit:
- Antihypertensive Effects of Tryptic Hydrolysate of Casein on Normotensive and Hypertensive Volunteers.Nippon Eiyo Shokuryo Gakkaishi, 1992
- Mouse proacrosin gene: Nucleotide sequence, diploid expression, and chromosomal localizationGenomics, 1991
- Biological regulation function and food.1 I.Bio active peptide derived from food protein.Kagaku to Seibutsu, 1991
- Molecular cloning of preproacrosin and analysis of its expression pattern in spermatogenesisEuropean Journal of Biochemistry, 1989
- Aufbau einer Cosmidbibliothek mit genomischer DNA vom Rind und deren Verwendung in der Tierzucht1Journal of Animal Breeding and Genetics, 1988
- Recent developments in the design of angiotensin‐converting enzyme inhibitorsMedicinal Research Reviews, 1985
- Split-gene evolution: Exon shuffling and intron insertion in serine protease genesNature, 1985
- Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats.Agricultural and Biological Chemistry, 1985
- Acrosin in the spermiohistogenesis of mammalsDifferentiation, 1983
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977