Relationship between bone mass and rates of bone change at appendicular measurement sites
Open Access
- 1 July 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 7 (7), 719-725
- https://doi.org/10.1002/jbmr.5650070702
Abstract
The rate of bone change among postmenopausal women may vary depending upon the initial bone mass. Examining this possibility is difficult, however, because of a negative statistical bias that occurs when change is regressed against the initial value of the same variable. In this article, four statistical methods were applied to measure the association between bone mass and the rate of bone change. The study population was Japanese-American women, who were monitored for approximately 5 years. Bone changes were determined for the calcaneus and the distal and proximal radius. The results were consistent across the bone sites but differed between statistical methods. Three of the four methods indicated that the women with the greater bone mass had the greater loss rates. The fourth method did not support this association. Possible reasons for the discordant results are discussed. Using the “best” estimate of the relationship, a gradual convergence of bone mass was projected over time toward the population mean. The convergence occurred because women with higher bone mass had a somewhat faster loss rate than women with lower bone mass. Overall, however, the variation in bone mass between individuals was large compared to the rate of convergence.Keywords
This publication has 20 references indexed in Scilit:
- Characteristics of respondents and nonrespondents in a prospective study of osteoporosisJournal of Clinical Epidemiology, 1991
- The contribution of bone loss to postmenopausal osteoporosisOsteoporosis International, 1990
- Selection of the Optimal Skeletal Site for Fracture Risk PredictionClinical Orthopaedics and Related Research, 1987
- A prospective study of change in bone mass with age in postmenopausal womenJournal of Chronic Diseases, 1982
- On the relation between blood pressure change and initial valueJournal of Chronic Diseases, 1980
- On the analysis of repeated measurements of the same subjectsJournal of Chronic Diseases, 1963
- A note on the analysis of repeated measurements of the same subjectsJournal of Chronic Diseases, 1962
- An alternative formula for the true correlation of initial values with gains.Journal of Experimental Psychology, 1925
- A formula to correct for the effect of errors of measurement on the correlation of initial values with gains.Journal of Experimental Psychology, 1924