MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia
- 3 November 2016
- journal article
- Published by American Society of Hematology in Blood
- Vol. 128 (18), 2253-2257
- https://doi.org/10.1182/blood-2016-04-711986
Abstract
Key Points AML-associated peripheral blood cytopenia is independent of bone marrow blast content, but strongly predicted by MPL expression on blast cells. MPLhi blasts scavenge TPO from serum, causing insufficient cytokine levels.Keywords
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