Plasma indicators of muscle damage in a model of nutritional myopathy in weaner sheep
- 1 January 1994
- journal article
- Published by Wiley in Australian Veterinary Journal
- Vol. 71 (1), 12-17
- https://doi.org/10.1111/j.1751-0813.1994.tb00894.x
Abstract
Subclinical nutritional myopathy was induced in 5-month-old sheep by feeding them a diet low in vitamin E and selenium. Subsequently clinical myopathy was induced by dosing with protected polyunsaturated fatty acids. Plasma activities of creatine kinase (CK), pyruvate kinase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase and aldolase, enzymes of muscle origin, all remained above their reference ranges in clinically affected sheep, but fluctuated widely. Similar fluctuations occurred in subclinically affected animals, resulting in some activities being within the reference ranges and some above, at different times. Plasma malondialdehyde, an indicator of lipid peroxidation, proved of no diagnostic value. Terminal plasma CK activities were significantly correlated with microscopic damage in the vastus lateralis (VL), but not the vastus intermedius (VI) or the tensor fascia lata (TFL) muscles. AST was the most highly correlated with damage in VI and VL. In two clinically affected sheep successfully treated with an oral dose of alpha-tocopherol acetate all enzymes decreased steadily to within their reference ranges, at rates probably related to their plasma half-lives. These results suggest that measurement of plasma CK activity would be useful in monitoring recovery of treated sheep.Keywords
This publication has 21 references indexed in Scilit:
- Skeletal muscle pathology in ovine congenital progressive muscular dystrophyActa Neuropathologica, 1988
- A study of nutritional myopathy in weaner sheepAustralian Veterinary Journal, 1986
- The effects of moisture, propionic acid, sodium hydroxide and anaerobiasis on the stability of vitamin E in stored barleyThe Journal of Agricultural Science, 1985
- Purification and analysis of phospholipids in the inner mitochondrial membrane fraction of bovine corpus luteum, and properties of cytochrome P‐450scc incorporated into vesicles prepared from these phospholipidsEuropean Journal of Biochemistry, 1985
- Reproduction of nutritional degenerative myopathy in the post ruminant calfPublished by Wiley ,1981
- LOW ALPHA‐TOCOPHEROL LEVELS IN LIVERS OF WEANER SHEEP WITH NUTRITIONAL MYOPATHYAustralian Veterinary Journal, 1980
- WHITE MUSCLE DISEASE OF SHEEP AND ASSOCIATED TISSUE SELENIUM LEVELS IN WESTERN AUSTRALIAAustralian Veterinary Journal, 1977
- Activities of enzymes concerned with pyruvate and oxaloacetate metabolism in the heart and liver of developing sheepBiochimica et Biophysica Acta (BBA) - General Subjects, 1975
- WHITE MUSCLE DISEASE (NUTRITIONAL MUSCULAR DYSTROPHY) OF SHEEP IN WESTERN AUSTRALIAAustralian Veterinary Journal, 1962
- A NOTE ON THE DEVELOPMENT OF MUSCULAR DYSTROPHY IN SHEEP ON AN EXPERIMENTAL DIETAustralian Veterinary Journal, 1942