Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion in small adults: a prospective, randomized trial
- 1 December 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Anaesthesiology
- Vol. 26 (12), 1061-1066
- https://doi.org/10.1097/eja.0b013e32833244c8
Abstract
Extreme haemodilution occurring with cardiopulmonary bypass imposes a primary risk factor for blood transfusion in small adult cardiac surgical patients. Priming of the cardiopulmonary bypass circuit with patients' own blood [retrograde autologous priming (RAP)] is a technique used to limit haemodilution and reduce transfusion requirements. We designed this study to evaluate the effects of RAP on reducing perioperative blood transfusion in small adults. One hundred and twenty patients with a body surface area of less than 1.5 m undergoing first-time, nonemergency cardiac surgery were randomized to either the standard priming group or the RAP group. All patients followed strict transfusion criteria. Homologous transfusion, haematocrit, plasma colloid osmotic pressure and postoperative clinical outcomes were evaluated perioperatively. Patient characteristics and operative parameters were equal for patients in both groups. With autologous priming, a mean volume of 614.8 +/- 138.8 ml of priming solution was replaced with autologous blood. This allowed a significantly higher haematocrit value during cardiopulmonary bypass (P < 0.05). Red blood cell transfusion was necessary in 83.3% of patients of the standard priming group on pump, whereas only 26.7% of patients of the RAP group required transfusion (P < 0.01). The overall transfusion rate of the RAP group was significantly less than that in the standard priming group during the hospitalization (90.0 vs. 50.0%, P < 0.01). Amongst patients who received transfusion on pump, the number of homologous units of packed red blood cells was less in the RAP group than that in the standard priming group intraoperatively and perioperatively (0.94 +/- 0.32 vs. 1.48 +/- 0.68 units, P = 0.03; 1.24 +/- 0.54 vs. 1.69 +/- 0.69 units, P = 0.15). Ten minutes after aortic cross-clamp, colloid osmotic pressure was reduced by 39.7 +/- 2.8% in the standard priming group and by 28.6 +/- 3.2% in the RAP group (P < 0.05). Clinical outcomes were similar with respect to pulmonary, renal and hepatic function, length of ICU stay and hospital stay. RAP resulted in a significant decrease in intraoperative haemodilution and conserved the use of blood. This technique should be considered for patients with a small body surface area (<1.5 m) undergoing open heart surgery.Keywords
This publication has 16 references indexed in Scilit:
- An evidence-based review of the practice of cardiopulmonary bypass in adults: A focus on neurologic injury, glycemic control, hemodilution, and the inflammatory responseThe Journal of Thoracic and Cardiovascular Surgery, 2006
- Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting*Critical Care Medicine, 2006
- Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit: Safety and Impact on Postoperative OutcomesJournal of Cardiothoracic and Vascular Anesthesia, 2006
- Oxygen Delivery During Cardiopulmonary Bypass and Acute Renal Failure After Coronary OperationsThe Annals of Thoracic Surgery, 2005
- Are we doing everything we can to conserve blood during bypass? A national surveyPerfusion, 2005
- Randomized prospective trial for blood transfusion during adult cardiopulmonary bypass surgeryThe Journal of Thoracic and Cardiovascular Surgery, 2005
- The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgeryThe Annals of Thoracic Surgery, 2003
- Retrograde autologous priming: is it useful in elective on-pump coronary artery bypass surgery?The Annals of Thoracic Surgery, 2003
- Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion after coronary artery surgeryThe Annals of Thoracic Surgery, 2002
- Retrograde Autologous Priming For Cardiopulmonary Bypass: A Safe And Effective Means Of Decreasing Hemodilution And Transfusion RequirementsThe Journal of Thoracic and Cardiovascular Surgery, 1998