Molecular mechanism and physiological role of pexophagy
Open Access
- 17 January 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (7), 1367-1373
- https://doi.org/10.1016/j.febslet.2010.01.019
Abstract
Pexophagy is a selective autophagy process wherein damaged and/or superfluous peroxisomes undergo vacuolar degradation. In methylotropic yeasts, where pexophagy has been studied most extensively, this process occurs by either micro‐ or macropexophagy: processes analogous to micro‐ and macroautophagy. Recent studies have identified specific factors and illustrated mechanisms involved in pexophagy. Although mechanistically pexophagy relies heavily on the core autophagic machinery, the latest findings about the role of auxiliary pexophagy factors have highlighted specialized membrane structures required for micropexophagy, and shown how cargo selectivity is achieved and how cargo size dictates the requirement for these factors during pexophagy. These insights and additional observations in the literature provide a framework for an understanding of the physiological role(s) of pexophagy.Keywords
This publication has 73 references indexed in Scilit:
- Turnover of organelles by autophagy in yeastCurrent Opinion in Cell Biology, 2009
- Atg32 Is a Mitochondrial Protein that Confers Selectivity during MitophagyDevelopmental Cell, 2009
- Peroxisome matrix and membrane protein biogenesisIUBMB Life, 2009
- Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stagesNature, 2009
- Role of BNIP3 and NIX in cell death, autophagy, and mitophagyCell Death & Differentiation, 2009
- Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomesProceedings of the National Academy of Sciences of the United States of America, 2008
- Mitophagy in Yeast Occurs through a Selective MechanismPublished by Elsevier BV ,2008
- The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential FunctionJournal of Biological Chemistry, 2008
- Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometryProceedings of the National Academy of Sciences of the United States of America, 2007
- PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagyThe Journal of cell biology, 2006