Involvement of activator protein in the activation of tryptophan hydroxylase by cAMP‐dependent protein kinase
- 30 July 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 268 (1), 185-188
- https://doi.org/10.1016/0014-5793(90)81004-8
Abstract
The tryptophan hydroxylase activity of the crude extract from rat brain stem was stimulated approximately 2-fold by incubation with cAMP analogues under protein phosphorylating conditions. The cAMP-dependent activation process of the enzyme needed not only cAMP-dependent protein kinase but also activator protein. The kinetic properties of the enzyme activated by cAMP-dependent protein kinase were very similar to those of the enzyme activated by calmodulin-dependent protein kinase II.Keywords
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