Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects
- 1 September 1993
- journal article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 36 (9), 857-862
- https://doi.org/10.1007/bf00400362
Abstract
The relationships between gastric emptying and intragastric distribution of glucose and oral glucose tolerance were evaluated in 16 healthy volunteers. While sitting in front of a gamma camera the subjects drank 350 ml water containing 75 g glucose and 20 MBq 99mTc-sulphur colloid. Venous blood samples for measurement of plasma glucose, insulin and gastric inhibitory polypeptide were obtained at — 2, 2, 5, 10, 15, 30, 45, 60, 75, 90, 105, 120 and 150 min. Gastric emptying approximated a linear pattern after a short lag phase (3.3±0.8 min). The 50% emptying time was inversely related to the proximal stomach 50% emptying time (r=−0.55, pr=0.72, pr=0.58, pr=0.58, pr=−0.56, pr=−0.53, pr=−0.65, pr=0.53, p<0.05). These results indicate in normal subjects that (i) gastric emptying accounts for about 34 % of the variance in peak plasma glucose after a 75-g oral glucose load (ii) plasma glucose levels at 120 min are inversely, rather than directly, related to gastric emptying (iii) the distal stomach influences gastric emptying of glucose.Keywords
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