Characterizing the profile of obese patients who are metabolically healthy
Top Cited Papers
- 26 October 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in International Journal of Obesity
- Vol. 35 (7), 971-981
- https://doi.org/10.1038/ijo.2010.216
Abstract
The presence of obesity-related metabolic disturbances varies widely among obese individuals. Accordingly, a unique subset of obese individuals has been described in the medical literature, which seems to be protected or more resistant to the development of metabolic abnormalities associated with obesity. These individuals, now known as ‘metabolically healthy but obese’ (MHO), despite having excessive body fatness, display a favorable metabolic profile characterized by high levels of insulin sensitivity, no hypertension as well as a favorable lipid, inflammation, hormonal, liver enzyme and immune profile. However, recent studies have indicated that this healthier metabolic profile may not translate into a lower risk for mortality. Mechanisms that could explain the favorable metabolic profile of MHO individuals are poorly understood. However, preliminary evidence suggests that differences in visceral fat accumulation, birth weight, adipose cell size and gene expression-encoding markers of adipose cell differentiation may favor the development of the MHO phenotype. Despite the uncertainty regarding the exact degree of protection related to the MHO status, identification of underlying factors and mechanisms associated with this phenotype will eventually be invaluable in helping us understand factors that predispose, delay or protect obese individuals from metabolic disturbances. Collectively, a greater understanding of the MHO individual has important implications for therapeutic decision making, the characterization of subjects in research protocols and medical education.Keywords
This publication has 87 references indexed in Scilit:
- Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese AdolescentsDiabetes Care, 2010
- Increased Whole‐Body Adiposity Without a Concomitant Increase in Liver Fat is Not Associated With Augmented Metabolic DysfunctionObesity, 2010
- The Effect of Randomization to Weight Loss on Total Mortality in Older Overweight and Obese Adults: The ADAPT StudyThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2010
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesityProceedings of the National Academy of Sciences of the United States of America, 2009
- Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36Diabetes, 2008
- Adipogenic Human Adenovirus Ad-36 Induces Commitment, Differentiation, and Lipid Accumulation in Human Adipose-Derived Stem CellsThe International Journal of Cell Cloning, 2008
- PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid MetabolismPLoS Genetics, 2007
- Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parametersInternational Journal of Obesity, 2006
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 2003
- Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.JCI Insight, 1983