Plasma protein kinase activity enhanced by interferon is found in platelets
- 1 November 1982
- journal article
- Published by Wiley in FEBS Letters
- Vol. 149 (2), 176-180
- https://doi.org/10.1016/0014-5793(82)81096-x
Abstract
A protein kinase activity analogous to that found in interferon‐treated HeLa cells is detectable in human plasma rich in platelets. This kinase activity is manifested by the phosphorylation of an endogenous M r 72 000 protein which could be conveniently assayed after partial purification on poly(G)—Sepharose. Here, we show that the protein kinase system in the plasma consists of at least 2 components. The protein kinase is found to be localised in the platelet whereas most of the substrate (the M r 72 000 protein) is found free in the plasma and a fraction of it associated with the surface of platelets.Keywords
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