Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia
- 1 May 1996
- journal article
- review article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 122 (5), 266-274
- https://doi.org/10.1007/bf01261402
Abstract
Polyomavirus enhancer binding protein 2 (PEBP2), also called core binding factor(CBF), is a heterodimer composed of the α and the β subunits. Structural alterations of each of the two subunits generated by recurrent chromosome translocations/inversion are associated with acute myeloid leukemia or acute lymphoblastic leukemia. Chimeric proteins containing a part of either the α or the β subunits have a potential to affect the transcriptional regulation through the PEBP2/CBF site. Structure and function of PEBP2/CBF and possible mechanisms of leukemogenesis caused by the chimeric proteins are summarized.Keywords
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