BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
Top Cited Papers
- 1 June 2005
- journal article
- review article
- Published by Elsevier BV in Cytokine & Growth Factor Reviews
- Vol. 16 (3), 251-263
- https://doi.org/10.1016/j.cytogfr.2005.01.009
Abstract
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various proteins, including transcription factor Runx, and transmit specific signals in target cells. The recent development of DNA microarray techniques has allowed us to identify many BMP target genes. BMP signaling is modulated by various molecules, including inhibitory Smads (I-Smads). Moreover, recent findings have revealed that BMP pathways interact with other signaling pathways, and such signaling cross-talk plays pivotal roles in growth and differentiation of target cells.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology
This publication has 127 references indexed in Scilit:
- Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteinsOncogene, 2004
- Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-β Signaling, as a Target of the β-Catenin Pathway in Colorectal Tumor CellsPublished by Elsevier BV ,2004
- DACH1 Inhibits Transforming Growth Factor-β Signaling through Binding Smad4Published by Elsevier BV ,2003
- Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertensionHuman Molecular Genetics, 2003
- Smurf1 Facilitates Myogenic Differentiation and Antagonizes the Bone Morphogenetic Protein-2-induced Osteoblast Conversion by Targeting Smad5 for DegradationPublished by Elsevier BV ,2003
- Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1The Journal of cell biology, 2003
- SANE, a Novel LEM Domain Protein, Regulates Bone Morphogenetic Protein Signaling through Interaction with Smad1Published by Elsevier BV ,2003
- Requirement of Bmpr1a for Müllerian duct regression during male sexual developmentNature Genetics, 2002
- Negative Regulation of Bone Morphogenetic Protein/Smad Signaling by Cas-interacting Zinc Finger Protein in OsteoblastsJournal of Biological Chemistry, 2002
- Ski/Sno and TGF-β signalingCytokine & Growth Factor Reviews, 2001