Influence of cardiac function on the diuretic and hemodynamic effects of the loop diuretic piretanide
Open Access
- 31 January 1987
- journal article
- research article
- Published by Wiley in Clinical Cardiology
- Vol. 10 (2), 83-88
- https://doi.org/10.1002/clc.4960100203
Abstract
The influence of caridac function on the diuretic and hemodynamic effects of the loop diuretic piretanide was investigated in nine patients with congestive heart failure. The diuretic response to piretanide correlated significantly with the pretreatment cardiac index (r=0.90). Furthermore, a significant correlation was found between the pretreatment fractional sodium excretion and the cardiac index (r=0.85). The fractional sodium excretion is reciprocal to the renal sodium and water reabsorption. No change in the hemodynamics was observed prior to the onset of diuresis. At 120 minutes after administration of piretanide, the reduction of mean pulmonary capillary wedge pressure (r=0.88) and mean right atrial pressure (r=0.80) was significantly related to the diuretic response. We conclude that the reduced diuretic response to piretanide in patients with low cardiac index is due to increased renal sodium and water reabsorption. The hemodynamic changes following the administration of piretanide are dependent on the diuresis.Keywords
This publication has 26 references indexed in Scilit:
- Role of angiotensin II in the altered renal function of congestive heart failure.Circulation Research, 1984
- Mechanisms of the Impaired Diuretic and Natriuretic Responses to a Sustained and Moderate Saline Infusion in Rats with Experimental CirrhosisHepatology, 1984
- Hemodynamic effects of massive peripheral edemaAmerican Heart Journal, 1983
- Resistance to DiureticsDrugs, 1981
- Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the RatJCI Insight, 1980
- Ineffectiveness of sublingual nitroglycerin in acute left ventricular failure in the presence of massive peripheral edemaThe American Journal of Cardiology, 1980
- Comparison of Hemodynamic Effects of Furosemide and Piretanide in Normovolemic PatientsJournal of Cardiovascular Pharmacology, 1980
- The Kidney in Heart FailureNew England Journal of Medicine, 1977
- The acute hemodynamic effects of ethacrynic acid and furosemide in patients with chronic postcapillary pulmonary hypertension.Circulation, 1976
- FRUSEMIDE IN ACUTE PULMONARY ŒDEMAThe Lancet, 1967