Network‐Based Modeling of the Human Gut Microbiome
- 20 May 2010
- journal article
- microbial systems-biology
- Published by Wiley in Chemistry & Biodiversity
- Vol. 7 (5), 1040-1050
- https://doi.org/10.1002/cbdv.200900324
Abstract
In this article, we used a network‐based approach to characterize the microflora abundance in colonic mucosal samples and correlate potential interactions between the identified species with respect to the healthy and diseased states. We analyzed the modelled network by computing several local and global network statistics, identified recurring patterns or motifs, fit the network models to a family of well‐studied graph models. This study has demonstrated, for the first time, an approach that differentiated the gut microbiota in alcoholic subjects and healthy subjects using topological network analysis of the gut microbiome.This publication has 24 references indexed in Scilit:
- Comparison of the Diversity of the Vaginal Microbiota in HIV‐Infected and HIV‐Uninfected Women with or without Bacterial VaginosisThe Journal of Infectious Diseases, 2008
- Worlds within worlds: evolution of the vertebrate gut microbiotaNature Reviews Microbiology, 2008
- NeAT: a toolbox for the analysis of biological networks, clusters, classes and pathwaysNucleic Acids Research, 2008
- GraphCrunch: A tool for large network analysesBMC Bioinformatics, 2008
- The Human Microbiome ProjectNature, 2007
- Evolution of Symbiotic Bacteria in the Distal Human IntestinePLoS Biology, 2007
- Modelling protein–protein interaction networks via a stickiness indexJournal of The Royal Society Interface, 2006
- Host-Bacterial Mutualism in the Human IntestineScience, 2005
- Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research, 2003
- Network motifs in the transcriptional regulation network of Escherichia coliNature Genetics, 2002