Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study
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Open Access
- 1 February 2012
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 147 (2), 113-119
- https://doi.org/10.1001/archsurg.2011.287
Abstract
Vascular disruption with concomitant hemorrhage is a leading cause of death in civilian and military trauma.1,2 Experience from the wars in Iraq and Afghanistan has led to advances in resuscitation for hemorrhagic shock, with identification of optimum ratios of blood components to be used in this setting.3-5 These new strategies are based on early and balanced administration of packed red blood cells (PRBCs), fresh frozen plasma (FFP), platelets, and cryoprecipitate to restore circulating volume and clotting factors.6 Despite these advances, the effectiveness of a medication to improve mortality in the setting of hemorrhagic shock has not been established.Keywords
This publication has 4 references indexed in Scilit:
- Antifibrinolytic therapy: new data and new conceptsThe Lancet, 2010
- Combat Injuries in Iraq and Afghanistan Help Rewrite the Book on War SurgeryJAMA, 2009
- An anti-inflammatory role for tranexamic acid in cardiac surgery?Critical Care, 2008
- TRAUMATIC HYPHAEMA TREATED WITH THE ANTIFIBRINOLYTIC DRUG TRANEXAMIC ACID IIActa Ophthalmologica, 1977