Blood compatibility of heparin-inspired, lactose containing, polyureas depends on the chemistry of the polymer backbone
- 13 May 2016
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Polymer Chemistry
- Vol. 7 (23), 3897-3905
- https://doi.org/10.1039/c6py00616g
Abstract
Sulfated glycopolymers were synthesized from diisocyanates and lactose containing diamines. Blood compatibility assays indicated highly sulfated glycopolymers with methylene bis(4-cyclohexyl isocyanate) backbones result in prolonged clotting times.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (1K08HL105672)
- Division of Materials Research (DMR-1206150)
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