Metal‐induced developmental toxicity in mammals: A review
- 1 June 1994
- journal article
- review article
- Published by Taylor & Francis Ltd in Journal of Toxicology and Environmental Health
- Vol. 42 (2), 123-141
- https://doi.org/10.1080/15287399409531868
Abstract
It is well established that certain metals are toxic to embryonic and fetal tissues and can induce teratogenicity in mammals. The main objective of this paper has been to summarize the toxic effects that excesses of certain metals may cause on mammalian development. The reviewed elements have been divided into four groups: (a) metals of greatest toxicological significance (arsenic, cadmium, lead, mercury, and uranium) that are widespread in the human environment, (b) essential trace metals (chromium, cobalt, manganese, selenium, and zinc), (c) other metals with evident biological interest (nickel and vanadium), and (d) metals of pharmacological interest (aluminum, gallium, and lithium). A summary of the therapeutic use of chelaling agents in the prevention of metal‐induced developmental toxicity has also been included. meso‐2,3‐Dimercaptosuccinic acid (DMSA) and sodium 2,3‐dimercaptopropane‐1‐sulfonate (DMPS) have been reported to be effective in alleviating arsenic‐ and mercury‐induced teratogenesis, whereas sodium 4,5‐dihydroxybenzene‐1,3‐disulfonate (Tiron) would protect against vanadium‐ and uranium‐induced developmental toxicity.Keywords
This publication has 98 references indexed in Scilit:
- Developmental toxicity evaluation of gallium nitrate in miceArchives of Toxicology, 1992
- meso-2,3-Dimercaptosuccinic acid and prevention of arsenite embryotoxicity and teratogenicity in the mouseFundamental and Applied Toxicology, 1991
- Lack of teratogenicity of aluminum hydroxide in miceLife Sciences, 1989
- Acute Arsenic Intoxication from Environmental Arsenic ExposureArchives of environmental health, 1989
- Evaluation of the Perinatal and Postnatal Effects of Uranium in Mice upon Oral AdministrationArchives of environmental health, 1989
- The effect of cadmium on the development of the facial prominences: Surface area measurements of day 10-8 A.M. hamster embryosTeratology, 1987
- Embryotoxicity and teratogenicity of lithium carbonate in wistar ratToxicology Letters, 1986
- Teratogenic effects of lithium in miceTeratology, 1982
- Teratogenic Effect of Lithium Carbonate in the Foetal MouseNature, 1970
- Preventive effect of penicillamine on the brain defect of fetal rat poisoned transplacentally with methyl mercuryLife Sciences, 1967