Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP
- 12 February 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5967), 866-868
- https://doi.org/10.1126/science.1181185
Abstract
Decoding a Second-Messenger's Message: Biofilms are aggregates of bacteria on a surface often associated with increased resistance to antibiotics and stress. In Vibrio cholerae , the bacterial species that causes cholera, biofilm formation is promoted by the bacterial second-messenger cyclic diguanylate (c-di-GMP) and involves the transcription regulator, VpsT. Krasteva et al. (p. 866 ) show that VpsT is itself a receptor for c-di-GMP and that binding of the small signaling molecule promotes VpsT dimerization, which is required for DNA recognition and transcriptional regulation. As well as activating components of the biofilm pathway, VpsT also down-regulates motility genes in a c-di-GMP–dependent manner.Keywords
This publication has 14 references indexed in Scilit:
- Biological Insights from Structures of Two-Component ProteinsAnnual Review of Microbiology, 2009
- Identification and Characterization of Cyclic Diguanylate Signaling Systems Controlling Rugosity in Vibrio choleraeJournal of Bacteriology, 2008
- Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMPScience, 2008
- Identification of FleQ from Pseudomonas aeruginosa as a c‐di‐GMP‐responsive transcription factorMolecular Microbiology, 2008
- The rbmBCDEF Gene Cluster Modulates Development of Rugose Colony Morphology and Biofilm Formation in Vibrio choleraeJournal of Bacteriology, 2007
- Regulation of Rugosity and Biofilm Formation in Vibrio cholerae : Comparison of VpsT and VpsR Regulons and Epistasis Analysis of vpsT , vpsR , and hapRJournal of Bacteriology, 2007
- Smooth to rugose phase variation in Vibrio cholerae can be mediated by a single nucleotide change that targets c‐di‐GMP signalling pathwayMolecular Microbiology, 2006
- Cyclic‐diGMP signal transduction systems in Vibrio cholerae: modulation of rugosity and biofilm formationMolecular Microbiology, 2006
- VpsT Is a Transcriptional Regulator Required for Expression of vps Biosynthesis Genes and the Development of Rugose Colonial Morphology in Vibrio cholerae O1 El TorJournal of Bacteriology, 2004
- CsgD, a regulator of curli and cellulose synthesis, also regulates serine hydroxymethyltransferase synthesis in Escherichia coli K-12Microbiology, 2003