Plasma Prolidase Activity and Oxidative Stress in Patients with Parkinson’s Disease
Top Cited Papers
Open Access
- 9 August 2015
- journal article
- research article
- Published by Hindawi Limited in Parkinson's Disease
- Vol. 2015, 1-6
- https://doi.org/10.1155/2015/598028
Abstract
Prolidase deficiency has been related to mental retardation and oxidative stress. The study aimed to observe plasma prolidase activity (PPA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with Parkinson’s disease (PD). 240 subjects with PD and 150 healthy volunteers were considered as cases and controls, respectively. PPA, TOS, TAS, and OSI were measured spectrophotometrically. PPA and TAS in cases were more significantly decreased than controls, while TOS and OSI were significantly increased. In cases, nonsignificant, positive correlation was observed between PPA and TOS and OSI while significant, negative correlation was observed between PPA and TAS. PPA in cases was nonsignificantly decreased with increased duration of PDwhile TAS was significantly decreasedand TOS and OSI were significantly increased. It was observed that higher age groups had decreased PPA, and TAS and increased TOS and OSI compared to lower age groups in cases. In summary, patients with PD have decreased PPA and increased oxidative stress compared to healthy volunteers. PPA was associated with oxidative stress markers in patients with PD. Decreased PPA and TAS and increased TOS and OSI were associated with progression of disease and higher age.
Keywords
This publication has 33 references indexed in Scilit:
- Serum Prolidase Activity, Oxidant and Antioxidant Status in Nonulcer Dyspepsia and Healthy VolunteersISRN Biochemistry, 2013
- Prolidase Could Act as a Diagnosis and Treatment Mediator in Lung FibrosisInflammation, 2012
- Neuroinflammation in Parkinson's diseaseParkinsonism & Related Disorders, 2012
- Serological Profiles of Urate, Paraoxonase-1, Ferritin and Lipid in Parkinson’s Disease: Changes Linked to Disease ProgressionNeurodegenerative Diseases, 2011
- Inborn Errors of Proline MetabolismJournal of Nutrition, 2008
- Diagnosis and treatment of Parkinson disease: molecules to medicineJCI Insight, 2006
- A new automated colorimetric method for measuring total oxidant statusClinical Biochemistry, 2005
- Mitochondria, Oxidative Damage, and Inflammation in Parkinson's DiseaseAnnals of the New York Academy of Sciences, 2003
- Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1996
- Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cellsActa Neuropathologica, 1990