The VHL-dependent regulation of microRNAs in renal cancer
Open Access
- 21 October 2010
- journal article
- Published by Springer Science and Business Media LLC in BMC Medicine
- Vol. 8 (1), 64
- https://doi.org/10.1186/1741-7015-8-64
Abstract
The commonest histological type of renal cancer, clear cell renal cell carcinoma (cc RCC), is associated with genetic and epigenetic changes in the von Hippel-Lindau (VHL) tumour suppressor. VHL inactivation leads to induction of hypoxia-inducible factors (HIFs) and a hypoxic pattern of gene expression. Differential levels of specific microRNAs (miRNAs) are observed in several tumours when compared to normal tissue. Given the central role of VHL in renal cancer formation, we examined the VHL-dependent regulation of miRNAs in renal cancer.This publication has 66 references indexed in Scilit:
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