Drug resistance in leishmaniasis
Top Cited Papers
Open Access
- 1 January 2010
- journal article
- symposium --lieshmaniasis
- Published by Medknow in Journal of Global Infectious Diseases
- Vol. 2 (2), 167-176
- https://doi.org/10.4103/0974-777x.62887
Abstract
The treatment options of leishmaniasis are limited and far from satisfactory. For more than 60 years, treatment of leishmaniasis has centered around pentavalent antimonials (Sb v ). Widespread misuse has led to the emergence of Sb v resistance in the hyperendemic areas of North Bihar. Other antileishmanials could also face the same fate, especially in the anthroponotic cycle. The HIV/ visceral leishmaniasis (VL) coinfected patients are another potential source for the emergence of drug resistance. At present no molecular markers of resistance are available and the only reliable method for monitoring resistance of isolates is the technically demanding in vitro amastigote-macrophage model. As the armametrium of drugs for leishmaniasis is limited, it is important that effective monitoring of drug use and response should be done to prevent the spread of resistance. Regimens of simultaneous or sequential combinations should be seriously considered to limit the emergence of resistance.Keywords
This publication has 104 references indexed in Scilit:
- Paromomycin: Uptake and resistance in Leishmania donovaniMolecular and Biochemical Parasitology, 2009
- Anthropometrically derived dosing and drug costing calculations for treating visceral leishmaniasis in Bihar, IndiaTropical Medicine & International Health, 2009
- Injectable Paromomycin for Visceral Leishmaniasis in IndiaThe New England Journal of Medicine, 2007
- Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1Biochemical Journal, 2004
- Genital manifestations of tropical diseasesSexually Transmitted Infections, 2004
- Aminosidine and its combination with sodium stibogluconate in the treatment of diffuse cutaneous leishmaniasis caused by Leishmania aethiopicaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1994
- ABC Transporters: From Microorganisms to ManAnnual Review of Cell Biology, 1992
- Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major: A double-blind control studyJournal of the American Academy of Dermatology, 1992
- Comparison of regimens of treatment with sodium stibogluconate in kala-azar.BMJ, 1984
- Evaluation of diamidine compound (pentamidine isethionate) in the treatment of resistant cases of kala-azar occurring in North Bihar, IndiaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1983