Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study
Open Access
- 1 July 2007
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 98 (1), 201-210
- https://doi.org/10.1017/s0007114507691788
Abstract
Established dietary predictors of plasma total homocysteine (tHcy) include folate, riboflavin, and vitamins B6 and B12, while information is scarce regarding other dietary components. The aim of this study was to examine the relation between a variety of food groups, food items and nutrients, and plasma tHcy in a large population-based study. The study population included 5812 men and women aged 47–49 and 71–74 years who completed a 169-item FFQ. tHcy was examined across quartiles of dietary components by multiple linear regression analyses adjusting for age, sex, energy intake, various risk factors for elevated tHcy, as well as for dietary and plasma B-vitamins. Among 4578 non-users of vitamin supplements, intake of vegetables, fruits, cereals, eggs, fish and milk, as well as chicken and non-processed meats were inversely associated with tHcy level. The estimated mean difference in tHcy per increasing quartile of intake ranged from − 0·11 (95 % CI − 0·21, − 0·01) μmol/l for milk to − 0·32 (95 % CI − 0·42, − 0·22) μmol/l for vegetables. Positive associations were found for sweets and cakes. Whole-grain bread was significantly inversely related to tHcy only after additional adjustment for dietary and plasma B-vitamins. The nutrients folate, vitamin B6, B12, and riboflavin were inversely related to tHcy. Complex carbohydrates were inversely, and fat positively associated with tHcy, also after adjustment for dietary and plasma B-vitamins. In conclusion, food items rich in B-vitamins and with a low content of fat and sugar were related to lower tHcy levels. Eggs, chicken, non-processed meat, fish and milk were inversely associated with tHcy.Keywords
This publication has 48 references indexed in Scilit:
- Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overviewJournal of Inherited Metabolic Disease, 2006
- Dietary Determinants of Plasma Homocysteine ConcentrationsSeminars in Vascular Medicine, 2005
- Homocysteine and Folic Acid: Implications for PregnancySeminars in Vascular Medicine, 2005
- Homocysteine-Lowering Trials for Prevention of Heart Disease and StrokeSeminars in Vascular Medicine, 2005
- Coffee consumption and human health - beneficial or detrimental? - Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitusMolecular Nutrition & Food Research, 2005
- Betaine: a key modulator of one-carbon metabolism and homocysteine statuscclm, 2005
- Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart DiseasePharmacological Reviews, 2002
- The Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine ConcentrationsNew England Journal of Medicine, 1999
- Microbiological assay for vitamin B12 performed in 96-well microtitre plates.Journal of Clinical Pathology, 1991
- Methionine metabolism in mammalsThe Journal of Nutritional Biochemistry, 1990