Mechanisms of Endocytosis
Top Cited Papers
- 1 June 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 78 (1), 857-902
- https://doi.org/10.1146/annurev.biochem.78.081307.110540
Abstract
Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-mediated endocytic mechanisms and dissect endocytic pathways that proceed independently of clathrin. These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis, and trans-endocytosis. We also critically review the role of caveolae and caveolin1 in endocytosis. We highlight the roles of lipids, membrane curvature-modulating proteins, small G proteins, actin, and dynamin in endocytic pathways. We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes.Keywords
This publication has 248 references indexed in Scilit:
- Clathrin-independent endocytosis: A unique platform for cell signaling and PM remodelingCellular Signalling, 2009
- The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic PathwayCurrent Biology, 2008
- Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for DegradationDevelopmental Cell, 2008
- Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexityHistochemistry and Cell Biology, 2008
- PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and FunctionCell, 2008
- Invasive and Adherent Bacterial Pathogens Co-Opt Host Clathrin for InfectionCell Host & Microbe, 2007
- Making and breaking contacts: the cellular biology of cadherin regulationCurrent Opinion in Cell Biology, 2007
- Myosin 1E interacts with synaptojanin‐1 and dynamin and is involved in endocytosisFEBS Letters, 2007
- Clathrin-Dependent and Clathrin-Independent Retrieval of Synaptic Vesicles in Retinal Bipolar CellsNeuron, 2005
- Caveolin, a protein component of caveolae membrane coatsCell, 1992