Sertraline, Paroxetine, and Venlafaxine in refugee posttraumatic stress disorder with depression symptoms
- 1 July 2001
- journal article
- clinical trial
- Published by Wiley in Journal of Traumatic Stress
- Vol. 14 (3), 445-452
- https://doi.org/10.1023/a:1011177420069
Abstract
Three new antidepressants were used in treating posttraumatic stress disorder (PTSD) and symptoms of depression in Bosnian refugees. Thirty-two Bosnian refugees seeking treatment at a mental health clinic participated in a case series study. All received open trials of Sertraline (n = 15), Paroxetine (n = 12), or Venlafaxine (n = 5), with standard clinical doses. Overall, Sertraline and Paroxetine produced statistically significant improvement at 6 weeks in PTSD symptom severity in depression, and in Global Assessment of Functioning. Venlafaxine produced improvement in PTSD symptom severity and in Global Assessment of Functioning, did not yield improvement in symptoms of major depressive disorder; and had a high rate of side effects. Notwithstanding improvement of symptoms, all 32 refugees remained PTSD positive at the diagnostic level at the 6-week follow-up.Keywords
This publication has 10 references indexed in Scilit:
- Ethnocultural considerations in the assessment of PTSD.Published by American Psychological Association (APA) ,2004
- The treatment of PTSD and related stress disorders: Current research and clinical knowledge.Published by American Psychological Association (APA) ,2004
- PTSD Symptoms in Bosnian Refugees 1 Year After Resettlement in the United StatesAmerican Journal of Psychiatry, 1998
- Trial of Trazodone for Posttraumatic Stress Disorder Using a Multiple Baseline Group DesignJournal of Clinical Psychopharmacology, 1996
- Sertraline in the treatment of rape victims with posttraumatic stress disorderJournal of Traumatic Stress, 1996
- Pharmacotherapy in the Treatment of Posttraumatic Stress DisorderPsychiatric Annals, 1995
- Psychiatric consequences of "ethnic cleansing": clinical assessments and trauma testimonies of newly resettled Bosnian refugeesAmerican Journal of Psychiatry, 1995
- Reliability and validity of a brief instrument for assessing post‐traumatic stress disorderJournal of Traumatic Stress, 1993
- Fluoxetine in post‐traumatic stress disorderJournal of Traumatic Stress, 1991
- An Inventory for Measuring DepressionArchives of General Psychiatry, 1961