Targeted Sonography for Small Hepatocellular Carcinoma Discovered by CT or MRI: Factors Affecting Sonographic Detection
- 1 May 2010
- journal article
- research article
- Published by American Roentgen Ray Society in American Journal of Roentgenology
- Vol. 194 (5), W396-W400
- https://doi.org/10.2214/ajr.09.3171
Abstract
OBJECTIVE. The purpose of this study was to evaluate the detection rate of targeted sonography for small (≤ 3 cm) hepatocellular carcinomas (HCCs) primarily discovered by CTor MRI and to assess factors affecting lesion visibility on targeted sonography. SUBJECTS AND METHODS. Between October 2005 and April 2008, targeted sonography for small (≤ 3 cm) HCC was prospectively performed in cirrhotic patients. Targeted sonography was performed by a radiologist with knowledge of the size and location of the HCC. Invisible HCCs were compared with visible HCCs with regard to size, distance from the diaphragm, segmental location, subcapsular location, cause of liver cirrhosis, presence or absence of previous treatment, Child-Pugh class, and serum α-fetoprotein by using univariate and multivariate analyses. RESULTS. A total of 93 consecutive patients (65 men and 28 women; mean age, 59 years) with 93 HCCs (mean size ± SD, 1.8 ± 0.6 cm) were enrolled in this study. Of those, 73 (78.5%) HCCs were visible on targeted sonography. The detection rate was 36.4% (4/11) for HCC ≤ 1.0 cm, 77.6% (38/49) for HCC between 1.1 and 2.0 cm, and 93.9% (31/33) for HCC between 2.1 and 3.0 cm. In both univariate and multivariate analyses, the size of the tumor and distance between the tumor and the diaphragm were statistically significant factors affecting sonographic visibility. CONCLUSION. The overall detection rate for small (≤ 3 cm) HCC on targeted sonography was 78.5%. Small size and subphrenic location of the tumor were two independent predictors of sonographic invisibility.Keywords
This publication has 22 references indexed in Scilit:
- Planning Sonography to Assess the Feasibility of Percutaneous Radiofrequency Ablation of Hepatocellular CarcinomasAmerican Journal of Roentgenology, 2008
- Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinomaHepatology, 2007
- Development of evidence‐based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in JapanHepatology Research, 2007
- Strategies for the management of hepatocellular carcinomaNature Clinical Practice Oncology, 2007
- Accuracy of Ultrasonography, Spiral CT, Magnetic Resonance, and Alpha-Fetoprotein in Diagnosing Hepatocellular Carcinoma: A Systematic Review. CMEThe American Journal of Gastroenterology, 2006
- Management of hepatocellular carcinomaHepatology, 2005
- Global Cancer Statistics, 2002CA: A Cancer Journal for Clinicians, 2005
- Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survivalHepatology, 2003
- Prognostic prediction and treatment strategy in hepatocellular carcinomaHepatology, 2002
- Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL ConferenceJournal of Hepatology, 2001