Collateral Blood Flow in the Distal Ileum of Neonatal Piglets: A Clue to the Pathogenesis of Necrotizing Enterocolitis
- 1 January 1992
- journal article
- research article
- Published by Informa UK Limited in Pediatric Pathology
- Vol. 12 (1), 15-27
- https://doi.org/10.3109/15513819209023278
Abstract
Normal blood flow was measured in two regions of the ileum (distal and proximal) of normal birth weight (NBW) and low birth weight (LBW) neonatal piglets. Compensatory collateral blood flow in response to occlusion of vessels in the mesenteric vascular arcades was also measured in distal and proximal ileum of NBW and LBW neonatal piglets. Under normal control conditions the blood flow in the distal ileum of NBW piglets is reduced (40% less than proximal) and in LBW animals this reduction is greater (55% less than proximal). Both proximal and distal ileum of NBW animals but the proximal ileum only of LBW animals could mount compensatory collateral flow, whereas the distal ileum of LBW animals was unable to do so. This decompensation in LBW distal ileum may explain the predilection of NEC lesions for the distal ileum and proximal colon.Keywords
This publication has 16 references indexed in Scilit:
- Neonatal gastrointestinal perforationJournal of Pediatric Surgery, 1989
- In vivo method for the assessment of platelet accumulationJournal of Pharmacological Methods, 1989
- Surgical treatment of necrotizing enterocolitis: A population-based study in the Grampian Region, ScotlandJournal of Pediatric Surgery, 1988
- Relationship of Birth Weight to the Pathogenesis of Necrotizing Enterocolitis in the Neonatal PigletPediatric Pathology, 1988
- Necrotising enterocolitisJournal of Hospital Infection, 1986
- Management and Outcome of Necrotizing EnterocolitisClinical Pediatrics, 1985
- Fine structural changes in the gastro-intestinal tract of the hypoxic puppy: A study of natural historyJournal of Pediatric Surgery, 1977
- Microcirculatory changes in the gastrointestinal tract of the hypoxic puppy: An electron microscope studyJournal of Pediatric Surgery, 1975
- The pathogenesis of ischemic gastroenterocolitis of the neonate: Selective gut mucosal ischemia in asphyxiated neonatal pigletsJournal of Pediatric Surgery, 1972
- Individual Comparisons by Ranking MethodsJournal of Economic Entomology, 1945