Donor age is a major determinant of success of oocyte donation/recipient programme
Open Access
- 2 November 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 27 (1), 118-125
- https://doi.org/10.1093/humrep/der359
Abstract
In recent years, particularly in developed countries, women have tended to delay childbirth until over 40 years of age. Our study aims to identify whether the donor's age or recipient's age influences the pregnancy and live birth rate following oocyte recipient cycles. A population study included 3889 fresh oocyte recipient cycles. Pregnancy and live delivery rates were compared in recipient age groups (P< 0.05) to 24.1% in donors aged <30 years, 20.7% in donors aged 35–39 years and 11.5% in donors aged ≥40 years. The multivariate analysis showed no significant differences in the success by recipient's age. Compared with cycles in donors aged 30–34 years, cycles in donors aged 35–39 years had 14 and 18% less chance to achieve a pregnancy [adjusted rate ratio (ARR) 0.86, 95% confidence interval (CI) 0.75–0.98] and a live delivery (ARR 0.82, 95% CI 0.71–0.96), while cycles in donors aged 40 years or older had 42 and 54% less chance to achieve a pregnancy (ARR 0.58, 95% CI 0.41–0.84) and a live delivery (ARR 0.46, 95% CI 0.29–0.73). Older recipients with younger donors did not have a poorer pregnancy outcome compared with younger recipients with younger donors. Choosing a donor aged <35 years would increase the chance of pregnancy and live delivery for older recipients.Keywords
This publication has 29 references indexed in Scilit:
- Survey report of gamete donors' and recipients' preferences regarding disclosure of third party reproduction outcomes and genetic risk informationJournal of Obstetrics and Gynaecology Research, 2011
- Contribution of male age to outcomes in assisted reproductive technologiesFertility and Sterility, 2011
- Clinical and immunologic aspects of egg donation pregnancies: a systematic reviewHuman Reproduction Update, 2010
- Effects of men and recipients’ age on the reproductive outcome of an oocyte donation programJournal of Assisted Reproduction and Genetics, 2008
- Relationship between age and semen parameters in men with normal sperm concentration: analysis of 6022 semen samplesAndrologia, 2007
- Efficiency of oocyte cryopreservation: a meta-analysisFertility and Sterility, 2006
- Fertility and ageingHuman Reproduction Update, 2005
- Transfer and uterine factors are the major recipient-related determinants of success with donor eggsFertility and Sterility, 2004
- Clinical outcomes among recipients of donated eggs: an analysis of the U.S. national experience, 1996–1998Fertility and Sterility, 2002
- Age and InfertilityScience, 1986