Functional magnetic resonance studies of the reorganization of the human hand sensorimotor area after unilateral brain injury in the perinatal period.
- 27 September 1994
- journal article
- clinical trial
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 91 (20), 9612-9616
- https://doi.org/10.1073/pnas.91.20.9612
Abstract
Functional magnetic resonance imaging was used to map the hand sensorimotor area of hemiparetic adolescents and young adults who had suffered unilateral brain damage in the perinatal period. Unlike normal subjects, who exhibit cortical activation primarily contralateral to voluntary finger movements, the hemiparetic patients' intact hemispheres were equally activated by contralateral and ipsilateral finger movements. Our findings are consistent with previous clinical observations and animal experiments which suggest that the immature brain is able to reorganize in response to focal injury.Keywords
This publication has 33 references indexed in Scilit:
- Processing strategies for time‐course data sets in functional mri of the human brainMagnetic Resonance in Medicine, 1993
- Time course EPI of human brain function during task activationMagnetic Resonance in Medicine, 1992
- Functional Mapping of the Human Visual Cortex by Magnetic Resonance ImagingScience, 1991
- Echo‐planar time course MRI of cat brain oxygenation changesMagnetic Resonance in Medicine, 1991
- Effects of changes in the periphery on development of the corticospinal motor system in the ratDevelopmental Brain Research, 1991
- Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fieldsMagnetic Resonance in Medicine, 1990
- Effects of neonatal hemispherectomy on location and number of corticospinal neurons in the ratDevelopmental Brain Research, 1989
- FACTORS AFFECTING COGNITIVE FUNCTIONING OF HEMIPLEGIC CHILDRENDevelopmental Medicine and Child Neurology, 1987
- The sensitive period: transfer of fixation after occlusion for strabismic amblyopia.British Journal of Ophthalmology, 1982
- Localization in somatic sensory and motor areas of human cerebral cortex as determined by direct recording of evoked potentials and electrical stimulationJournal of Neurosurgery, 1979