CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation
Open Access
- 7 July 2011
- journal article
- Published by American Society of Hematology in Blood
- Vol. 118 (1), 80-87
- https://doi.org/10.1182/blood-2010-12-322339
Abstract
The proliferation and differentiation of adult stem cells is balanced to ensure adequate generation of differentiated cells, stem cell homeostasis, and guard against malignant transformation. CD48 is broadly expressed on hematopoietic cells but excluded from quiescent long-term murine HSCs. Through its interactions with CD244 on progenitor cells, it influences HSC function by altering the BM cytokine milieu, particularly IFNγ. In CD48-null mice, the resultant misregulation of cytokine signaling produces a more quiescent HSC, a disproportionate number of short-term progenitors, and hyperactivation of Pak1, leading to hematologic malignancies similar to those found in patients with X-linked lymphoproliferative disease. CD48 plays a vital role as an environmental sensor for regulating HSC and progenitor cell numbers and inhibiting tumor development.Keywords
This publication has 53 references indexed in Scilit:
- Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infectionNature, 2010
- PAK signaling in oncogenesisOncogene, 2009
- IFNα activates dormant haematopoietic stem cells in vivoNature, 2009
- Pak protein kinases and their role in cancerCancer and Metastasis Reviews, 2009
- Mouse hematopoietic stem cell identification and analysisCytometry Part A, 2008
- Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their ProgenyCell Stem Cell, 2007
- Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profilingNature Methods, 2006
- Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem CellsPLoS Biology, 2004
- Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.The Journal of Experimental Medicine, 1996
- CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.The Journal of Experimental Medicine, 1992