West Nile Virus Viremia in Eastern Chipmunks (Tamias striatus) Sufficient for Infecting Different Mosquitoes
Open Access
- 1 June 2007
- journal article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 13 (6), 831-837
- https://doi.org/10.3201/eid1306.061008
Abstract
In eastern chipmunks (Tamias striatus) inoculated intramuscularly with 101.5 to 105.7 PFU of West Nile virus (WNV), serum titers developed sufficient to infect Aedes triseriatus (Say), Ae. vexans (Meigen), and Culex pipiens (L.). Mean titers (95% confidence interval) of 8 chipmunks were 103.9(3.3–4.5), 106.7(6.4–7.0), and 105.8(4.1–7.5) PFU/mL on days 1–3 postinoculation (p.i.) and 105.8 PFU/mL in 1 chipmunk on day 4 p.i. Mean estimated days that WNV titers were >104.8 and >105.6 were 1.7 (1.1–2.3) and 1.4 (1.0–1.6). The longest period of viremia >104.8 PFU/mL was 3–4 days. WNV antigen was detected in the small intestine of 2 chipmunks and the kidneys of 4 chipmunks by immunohistochemistry. WNV also was detected in urine, saliva, and feces of some chipmunks. These data suggest chipmunks might play a role in enzootic WNV cycles and be an amplifying host for mosquitoes that could infect humans.Keywords
This publication has 32 references indexed in Scilit:
- Potentiation of West Nile Encephalitis by Mosquito FeedingViral Immunology, 2006
- West Nile Virus Epidemics in North America Are Driven by Shifts in Mosquito Feeding BehaviorPLoS Biology, 2006
- Eastern Cottontail Rabbits (Sylvilagus floridanus) Develop West Nile Virus Viremias Sufficient for Infecting Select Mosquito SpeciesVector-Borne and Zoonotic Diseases, 2005
- Persistent West Nile Virus Infection in the Golden Hamster: Studies on Its Mechanism and Possible Implications for Other Flavivirus InfectionsThe Journal of Infectious Diseases, 2005
- Emerging Vectors in the Culex pipiens ComplexScience, 2004
- West Nile Virus Infection in Eastern Fox Squirrels (Sciurus niger)Veterinary Pathology, 2003
- Epitope-Blocking Enzyme-Linked Immunosorbent Assays for the Detection of Serum Antibodies to West Nile Virus in Multiple Avian SpeciesJournal of Clinical Microbiology, 2003
- Vector Competence of Selected North American Culex and Coquillettidia Mosquitoes for West Nile VirusEmerging Infectious Diseases, 2001
- West Nile Virus Infection in the Golden Hamster (Mesocricetus auratus): A Model for West Nile EncephalitisEmerging Infectious Diseases, 2001
- Study on West Nile virus persistence in monkeysArchiv für die gesamte Virusforschung, 1983