From maps to mechanisms through neuroimaging of schizophrenia
- 10 November 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 468 (7321), 194-202
- https://doi.org/10.1038/nature09569
Abstract
Functional and structural brain imaging has identified neural and neurotransmitter systems involved in schizophrenia and their link to cognitive and behavioural disturbances such as psychosis. Mapping such abnormalities in patients, however, cannot fully capture the strong neurodevelopmental component of schizophrenia that pre-dates manifest illness. A recent strategy to address this issue has been to focus on mechanisms of disease risk. Imaging genetics techniques have made it possible to define neural systems that mediate heritable risk linked to candidate and genome-wide-supported common variants, and mechanisms for environmental risk and gene–environment interactions are emerging. Characterizing the neural risk architecture of schizophrenia provides a translational research strategy for future treatments.This publication has 113 references indexed in Scilit:
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