Collagen-Templated Bioactive Titanium Dioxide Porous Networks for Drug Delivery
- 5 September 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Applied Materials & Interfaces
- Vol. 4 (9), 4717-4725
- https://doi.org/10.1021/am301093k
Abstract
A Type I collagen gel was used as a template for fabricating porous titanium dioxide networks. Conducting sol–gel chemistry within the template, followed by a mild solvothermal treatment (selected TiO2–collagen hybrids only), and then calcination to remove the template, produced anatase TiO2 porous networks composed of mesoporous fibers. The collagen morphology was retained. TiO2 fibers had walls up to 300 nm in thickness and hollow cores where the template was removed. Crystallite size, specific surface area (12.3–110 m2 g–1), mesopore diameter (4.2–8.8 nm), and pore volume of the networks varied under different synthesis conditions; solvothermal treatment of the hybrid doubled the surface area and mesopore diameter of the final material. Biomineralization was studied by immersion in a simulated body fluid. All networks displayed in vitro bioactivity, and hence potential bone-bonding capability, with apatite clusters growing on the fibers. Drug delivery was assessed by the adsorption and release of anti-inflammatory ibuprofen. Ibuprofen was stored both at the fiber surface and in mesopores below 15 nm in diameter, while release was a sustained diffusion process. The network solvothermally treated as a hybrid adsorbed ibuprofen up to 58.9 mg g–1. The TiO2 networks compared favorably with literature drug delivery vehicles when ibuprofen loading was normalized against surface area. Therefore, porous TiO2 networks have potential as materials for biomedical applications.Keywords
This publication has 62 references indexed in Scilit:
- Effect of Silica and Hydroxyapatite Mineralization on the Mechanical Properties and the Biocompatibility of Nanocomposite Collagen ScaffoldsACS Applied Materials & Interfaces, 2011
- Mesoporous titanium dioxide coating for metallic implantsJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2011
- In vitro mineralization of dense collagen substrates: A biomimetic approach toward the development of bone-graft materialsActa Biomaterialia, 2011
- Preparation of Mineralized Nanofibers: Collagen Fibrils Containing Calcium PhosphateNano Letters, 2011
- The preparation of TiO2/SiO2 composite hollow spheres with hydrophobic inner surface and their application in controlled releaseMaterials Research Bulletin, 2010
- Preparation of TiO2 nanocapsules for loading and release of antimicrobial triclosan moleculesMaterials Letters, 2007
- Preparation of novel hollow mesoporous silica spheres and their sustained-release propertyNanotechnology, 2005
- Hydroxyapatite/collagen composite materials formation in simulated body fluid environmentMaterials Letters, 2003
- Preparation of Novel Hollow Fiber Silica Using Collagen Fibers as a TemplateChemistry Letters, 1999
- Formation of biologically active bone-like apatite on metals and polymers by a biomimetic processThermochimica Acta, 1996