Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Top Cited Papers
Open Access
- 25 September 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Bone Research
- Vol. 1 (3), 216-248
- https://doi.org/10.4248/br201303002
Abstract
The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive(second generation)biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials(third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity.Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.Keywords
This publication has 157 references indexed in Scilit:
- Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A reviewActa Biomaterialia, 2012
- Adverse reactions and events related to musculoskeletal allografts: reviewed by the World Health Organisation Project NOTIFYInternational Orthopaedics, 2011
- Reaming Irrigator Aspirator system: Early experience of its multipurpose useInjury, 2011
- The biology of fracture healingInjury, 2011
- Reamer-irrigator-aspirator indications and clinical results: a systematic reviewInternational Orthopaedics, 2011
- Custom-made composite scaffolds for segmental defect repair in long bonesInternational Orthopaedics, 2010
- An update on bone substitutes for spinal fusionEuropean Spine Journal, 2009
- Bone Graft Harvest Using a New Intramedullary SystemClinical Orthopaedics and Related Research, 2008
- Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplastyJournal of Orthopaedic Research, 2008
- The Clinical Use of Allografts, Demineralized Bone Matrices, Synthetic Bone Graft Substitutes and Osteoinductive Growth Factors: A Survey StudyHSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery, 2005