Osteoarthritis, inflammation and obesity
- 1 January 2013
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Rheumatology
- Vol. 25 (1), 114-118
- https://doi.org/10.1097/bor.0b013e32835a9414
Abstract
Obesity is one of the main risk factors of the incidence and prevalence of knee osteoarthritis. Recent epidemiological data showing an increased risk of hand osteoarthritis in obese patients opened the door to a role of systemic inflammatory mediators, adipokines, released by adipose tissue. Recent experimental studies confirm the critical roles of adipokines in the pathophysiologic features of osteoarthritis, with an emphasis on a new member, chemerin. Animal models of diet-induced obesity show that overload cannot completely explain the aggravation of spontaneous or posttraumatic knee osteoarthritis. We now have data suggesting that some adipokines may be surrogate biomarkers for severity of osteoarthritis. Preclinical studies targeting adipokines are now expected to provide new hope for patients with osteoarthritis, especially those with metabolic syndrome.Keywords
This publication has 46 references indexed in Scilit:
- Biomechanical factors in osteoarthritisBest Practice & Research Clinical Rheumatology, 2011
- Inflammation in osteoarthritisCurrent Opinion in Rheumatology, 2011
- Osteoarthritis: an update with relevance for clinical practiceThe Lancet, 2011
- Role of heme oxygenase-1 in inflammatory response induced by mechanical stretch in synovial cellsInflammation Research, 2011
- Role of proinflammatory cytokines in the pathophysiology of osteoarthritisNature Reviews Rheumatology, 2010
- Obesity punches above its weight in osteoarthritisNature Reviews Rheumatology, 2010
- Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysisOsteoarthritis and Cartilage, 2009
- Knee osteoarthritis in obese women with cardiometabolic clusteringArthritis Care & Research, 2009
- Association between weight or body mass index and hand osteoarthritis: a systematic reviewAnnals Of The Rheumatic Diseases, 2009
- Obesity and osteoarthritis: more complex than predicted!Annals Of The Rheumatic Diseases, 2006