The Emerging Nature of Astrocyte Diversity
Top Cited Papers
- 8 July 2019
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 42 (1), 187-207
- https://doi.org/10.1146/annurev-neuro-070918-050443
Abstract
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a homogeneous population tiling the entire central nervous system (CNS). However, this view has been challenged in the last few years with the availability of RNA sequencing, immunohistochemistry, electron microscopy, morphological reconstruction, and imaging data. These studies suggest that astrocytes represent a diverse population of cells and that they display brain area– and disease–specific properties and functions. In this review, we summarize these observations, emphasize areas where clear conclusions can be made, and discuss potential unifying themes. We also identify knowledge gaps that need to be addressed in order to exploit astrocyte diversity as a biological phenomenon of physiological relevance in the CNS. We thus provide a summary and a perspective on astrocyte diversity in the vertebrate CNS.Keywords
This publication has 108 references indexed in Scilit:
- Monitoring local synaptic activity with astrocytic patch pipettesNature Protocols, 2012
- Heterogeneity of Astrocytic Form and FunctionMethods in Molecular Biology, 2011
- Astrocytic regulation of cortical UP statesProceedings of the National Academy of Sciences of the United States of America, 2011
- Glial and neuronal control of brain blood flowNature, 2010
- Regulation of synaptic connectivity by gliaNature, 2010
- A genetically targeted optical sensor to monitor calcium signals in astrocyte processesNature Neuroscience, 2010
- Motor Behavior Activates Bergmann Glial NetworksNeuron, 2009
- Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain CodeCell, 2008
- Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injuryProceedings of the National Academy of Sciences of the United States of America, 2006
- Neuronal specification in the spinal cord: inductive signals and transcriptional codesNature Reviews Genetics, 2000