Early Detection of Alzheimer’s Disease Using Non-invasive Near-Infrared Spectroscopy
Open Access
- 9 November 2018
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Aging Neuroscience
- Vol. 10, 366
- https://doi.org/10.3389/fnagi.2018.00366
Abstract
Mild cognitive impairment (MCI) is a cognitive disorder characterized by memory impairment, wherein patients have an increased likelihood of developing Alzheimer’s disease (AD). The classification of MCI and different AD stages is therefore fundamental for understanding and treating the disease. This study aimed to comprehensively investigate the hemodynamic response patterns among various subject groups. Functional near-infrared spectroscopy (fNIRS) was employed to measure signals from the frontal and bilateral parietal cortices of healthy controls (n = 8), patients with MCI (n = 9), mild (n = 6), and moderate/severe AD (n = 7) during a digit verbal span task (DVST). The concentration changes of oxygenated hemoglobin (HbO) in various subject groups were thoroughly explored and tested. Result revealed that abnormal patterns of hemodynamic response were observed across all subject groups. Greater and steeper reductions in HbO concentration were consistently observed across all regions of interest (ROIs) as disease severity developed from MCI to moderate/severe AD. Furthermore, all the fNIRS-derived indexes were found to be significantly and positively correlated to the clinical scores in all ROIs (R ≥ 0.4, P < 0.05). These findings demonstrate the feasibility of utilizing fNIRS for the early detection of AD, suggesting that fNIRS-based approaches hold great promise for exploring the mechanisms underlying the progression of AD.Keywords
This publication has 51 references indexed in Scilit:
- Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates: Table 1Journal of Neurology, Neurosurgery & Psychiatry, 2012
- Distinguishing Alzheimer’s disease from other major forms of dementiaExpert Review of Neurotherapeutics, 2011
- A quantitative comparison of NIRS and fMRI across multiple cognitive tasksNeuroImage, 2010
- Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice?Alzheimer's Research & Therapy, 2010
- Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRINeuroImage, 2006
- Event-related functional near-infrared spectroscopy (fNIRS): Are the measurements reliable?NeuroImage, 2006
- Within-subject reproducibility of near-infrared spectroscopy signals in sensorimotor activation after 6 monthsJournal of Biomedical Optics, 2006
- Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imagingJournal of Biomedical Optics, 2005
- Mild cognitive impairment as a diagnostic entityJournal of Internal Medicine, 2004
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975