Injectable Nano-Network for Glucose-Mediated Insulin Delivery
Top Cited Papers
- 2 May 2013
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 7 (5), 4194-4201
- https://doi.org/10.1021/nn400630x
Abstract
Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial “closed-loop” system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. In vitro insulin release can be modulated in a pulsatile profile in response to glucose concentrations. In vivo studies validated that these formulations provided improved glucose control in type 1 diabetic mice subcutaneously administered with a degradable nano-network. A single injection of the developed nano-network facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 10 days.Keywords
This publication has 32 references indexed in Scilit:
- Monosaccharide-Responsive Release of Insulin from Polymersomes of Polyboroxole Block Copolymers at Neutral pHJournal of the American Chemical Society, 2012
- Nanotechnology‐Enabled Closed Loop Insulin Delivery Device: In Vitro and In Vivo Evaluation of Glucose‐Regulated Insulin Release for Diabetes ControlAdvanced Functional Materials, 2010
- Chemically controlled closed-loop insulin deliveryJournal of Controlled Release, 2008
- Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic ApplicationsJournal of the American Chemical Society, 2008
- Phase Behavior and 3D Structure of Strongly Attractive Microsphere−Nanoparticle MixturesLangmuir, 2005
- Dextran dextrinase and dextran of Gluconobacter oxydansJournal of Industrial Microbiology & Biotechnology, 2005
- Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidasePolymer, 2000
- Totally Synthetic Polymer Gels Responding to External Glucose Concentration: Their Preparation and Application to On−Off Regulation of Insulin ReleaseJournal of the American Chemical Society, 1998
- Sensitive Glucose-Induced Change of the Lower Critical Solution Temperature of Poly[N,N-(dimethylacrylamide)-co-3-(acrylamido)-phenylboronic acid] in Physiological SalineMacromolecules, 1994
- A microcapsule self-regulating delivery system for insulinJournal of Controlled Release, 1990