High α‐defensin levels in patients with systemic lupus erythematosus
Open Access
- 31 March 2009
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 127 (1), 116-122
- https://doi.org/10.1111/j.1365-2567.2008.02997.x
Abstract
Innate immunity plays a role in systemic lupus erythematosus (SLE). Our objective was to determine the levels of defensins, which are antimicrobial and immunomodulatory polypeptides, in SLE. Sera from SLE patients and healthy controls were tested for pro-inflammatory human β-defensin 2 (hBD-2) and for α-defensin human neutrophil peptide 1 (HNP-1). hBD-2 could not be detected by enzyme-linked immunosorbent assay (ELISA) and its mRNA levels were low in SLE patients and similar to those found in controls. In contrast, the mean α-defensin level in the sera of all SLE patients (11·07 ± 13·92 ng/μl) was significantly higher than that of controls (0·12 ± 0·07 ng/μl). Moreover, 60% of patients demonstrated very high serum levels (18·5 ± 13·36 ng/μl) and 50% showed elevated gene expression in polymorphonuclear cells. High α-defensin levels correlated with disease activity, but not with neutrophil count. Thus, activation and degranulation of neutrophils led to α-defensin secretion in SLE patients. Given the immunomodulatory role of α-defensins, it is possible that their secretion may activate the adaptive immune system leading to a systemic response.Keywords
This publication has 36 references indexed in Scilit:
- Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediatorsThrombosis and Haemostasis, 2006
- Mouse intestinal cryptdins exhibit circadian oscillationThe FASEB Journal, 2005
- Arthropod and mollusk defensins – evolution by exon-shufflingTrends in Genetics, 2003
- Defensins: antimicrobial peptides of innate immunityNature Reviews Immunology, 2003
- Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus BloodThe Journal of Experimental Medicine, 2003
- Current status of defensins and their role in innate and adaptive immunityFEMS Microbiology Letters, 2002
- CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial EpitheliumPublished by Elsevier BV ,2000
- Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated NeutrophilsPublished by Elsevier BV ,1996
- Derivation of the sledai. A disease activity index for lupus patientsArthritis & Rheumatism, 1992
- Monocyte-chemotactic activity of defensins from human neutrophils.JCI Insight, 1989