The Prevalence of Olfactory and Gustatory Dysfunction in COVID‐19 Patients: A Systematic Review and Meta‐analysis
Top Cited Papers
Open Access
- 5 May 2020
- journal article
- review article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 163 (1), 3-11
- https://doi.org/10.1177/0194599820926473
Abstract
To determine the pooled global prevalence of olfactory and gustatory dysfunction in patients with the 2019 novel coronavirus (COVID-19). Literature searches of PubMed, Embase, and Scopus were conducted on April 19, 2020, to include articles written in English that reported the prevalence of olfactory or gustatory dysfunction in COVID-19 patients. Search strategies developed for each database contained keywords such as anosmia, dysgeusia, and COVID-19. Resulting articles were imported into a systematic review software and underwent screening. Data from articles that met inclusion criteria were extracted and analyzed. Meta-analysis using pooled prevalence estimates in a random-effects model were calculated. Ten studies were analyzed for olfactory dysfunction (n = 1627), demonstrating 52.73% (95% CI, 29.64%-75.23%) prevalence among patients with COVID-19. Nine studies were analyzed for gustatory dysfunction (n = 1390), demonstrating 43.93% (95% CI, 20.46%-68.95%) prevalence. Subgroup analyses were conducted for studies evaluating olfactory dysfunction using nonvalidated and validated instruments and demonstrated 36.64% (95% CI, 18.31%-57.24%) and 86.60% (95% CI, 72.95%-95.95%) prevalence, respectively. Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. To our knowledge, this is the first meta-analysis to report on the prevalence of these symptoms in COVID-19 patients.Keywords
This publication has 37 references indexed in Scilit:
- Contemporary assessment of the prevalence of smell and taste problems in adultsThe Laryngoscope, 2014
- Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in HumansPublished by Springer Science and Business Media LLC ,2014
- Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreementJournal of Clinical Epidemiology, 2012
- Epidemiological Studies of Smell: Discussion and PerspectivesAnnals of the New York Academy of Sciences, 2009
- Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2Journal of Virology, 2008
- Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisThe Journal of Pathology, 2004
- Meta-analysis of Observational Studies in EpidemiologyA Proposal for ReportingJAMA, 2000
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986
- Transformations Related to the Angular and the Square RootThe Annals of Mathematical Statistics, 1950