Understanding immunosenescence to improve responses to vaccines
Top Cited Papers
- 18 April 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 14 (5), 428-436
- https://doi.org/10.1038/ni.2588
Abstract
In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate protective immunity. The age-dependent decrease in immunological competence, often referred to as 'immunosenescence', results from the progressive deterioration of innate and adaptive immune responses. Most insights into mechanisms of immunological aging have been derived from studies of mouse models. In this Review, we explore how well such models are applicable to understanding the aging process throughout the 80–100 years of human life and discuss recent advances in identifying and characterizing the mechanisms that underlie age-associated defective adaptive immunity in humans.Keywords
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