Synthesis of Both the Enantiomers of Aseanostatin P5 (Sarcinic Acid), an Inhibitor of Myeloperoxidase Release, and Four Diastereomers of Aggreceride A, a Platelet Aggregation Inhibitor

Abstract

Both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase (MPO) release from human polymorphonuclear leukocytes (PMN), with high optical purity were synthesized by starting from (S)-2-methylbutanol and methyl (S)-3-hydroxy-2-methylpropanoate. They were converted to four diastereomers of aggreceride A, a platelet aggregation inhibitor.