Intravenous Immunoglobulin for Treatment of Recurrent Pregnancy Loss
- 1 December 1995
- journal article
- clinical trial
- Published by Wiley in American Journal of Reproductive Immunology
- Vol. 34 (6), 333-337
- https://doi.org/10.1111/j.1600-0897.1995.tb00960.x
Abstract
Efficacy of immunotherapy for treatment of recurrent spontaneous abortion (SA) has been controversial. The low treatment effect of white blood cell immunization lead to investigations of alternative treatments including intravenous (i.v.) immunoglobulin (Ig). To evaluate the efficacy of IVIg for treatment of recurrent SA, a prospective, randomized, double blinded, placebo-controlled trial was performed. Ninety-five women experiencing two or more consecutive spontaneous abortions, with no known cause were randomized and received either IVIg 500 mg/kg/month or placebo (albumin). Of 95 women participating in the study, 47 received IVIg and 48 received placebo. Medication was discontinued in 34 women who failed to conceive within four cycles. The remaining 61 women achieved pregnancy. Pregnancy outcomes included 29 deliveries and 32 recurrent SA. Among women delivering live births 18 (62%) received IVIg and 11 (38%) received placebo. By contrast, 21 (66%) women experiencing recurrent SAs received placebo and 11 (34%) received IVIg. Among 61 women who conceived, 29 received IVIg and 32 received placebo. Of the 29 women who conceived and received IVIg, 18 (62%) delivered live births and 11 (38%) experienced recurrent SA. Of 32 women who conceived and received placebo 11 (34%) delivered live births and 21 (66%) had recurrent SA. The difference in live birth rates between women receiving IVIg and placebo was significant (P = 0.04, odds ratio 3.1). IVIg is effective in enhancing the percentage of live births among women experiencing unexplained recurrent SA.Keywords
This publication has 28 references indexed in Scilit:
- Quantitation of Soluble HLA Class I Antigen in Human Albumin and Immunoglobulin Preparations for Intravenous Use by Solid‐Phase ImmunoassayVox Sanguinis, 1992
- IVIG to prevent recurrent spontaneous abortionThe Lancet, 1991
- Recurrent Spontaneous AbortionAmerican Journal of Reproductive Immunology, 1989
- THE USE AND MECHANISMS OF ACTION OF INTRAVENOUS IMMUNOGLOBULIN: AN UPDATEBritish Journal of Haematology, 1989
- LUPUS ANTICOAGULANT AND RECURRENT FETAL LOSS: SUCCESSFUL TREATMENT WITH GAMMAGLOBULINThe Lancet, 1988
- Beneficial effect of intravenous gammaglobulin in a patient with complement-mediated autoimmune thrombocytopenia due to IgM-anti-platelet antibodiesBritish Journal of Haematology, 1988
- Short‐term reproductive prognosis when no cause can be found for recurrent miscarriageBJOG: An International Journal of Obstetrics and Gynaecology, 1988
- Suppressor cell function after intravenous gammaglobulin treatment in adult chronic idiopathic thrombocytopenic purpuraBritish Journal of Haematology, 1985
- CONTROLLED TRIAL OF TREATMENT OF RECURRENT SPONTANEOUS ABORTION BY IMMUNISATION WITH PATERNAL CELLSThe Lancet, 1985
- Effect of Immunoglobulin Substitution during Plasmapheresis on Serum Immunoglobulin and Complement ConcentrationsNephron, 1985