Thyroid Disease and the Heart
Top Cited Papers
- 9 October 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 116 (15), 1725-1735
- https://doi.org/10.1161/circulationaha.106.678326
Abstract
The cardiovascular signs and symptoms of thyroid disease are some of the most profound and clinically relevant findings that accompany both hyperthyroidism and hypothyroidism. On the basis of the understanding of the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system, it is possible to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm disturbances that result from thyroid dysfunction. The importance of the recognition of the effects of thyroid disease on the heart also derives from the observation that restoration of normal thyroid function most often reverses the abnormal cardiovascular hemodynamics. In the present review, we discuss the appropriate thyroid function tests to establish a suspected diagnosis as well as the treatment modalities necessary to restore patients to a euthyroid state. We also review the alterations in thyroid hormone metabolism that accompany chronic congestive heart failure and the approach to the management of patients with amiodarone-induced alterations in thyroid function tests.This publication has 102 references indexed in Scilit:
- Rapid nongenomic actions of thyroid hormoneProceedings of the National Academy of Sciences of the United States of America, 2006
- Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapyEuropean Journal of Internal Medicine, 2006
- Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humansJCI Insight, 2005
- Subclinical Hypothyroidism and Cardiovascular RiskTreatments in Endocrinology, 2004
- Cellular Action of Thyroid Hormone on the HeartThyroid®, 2002
- Beta-Adrenergic Receptor Blocking Drugs in the Management of HyperthyroidismThe Endocrinologist, 1994
- Immunoregulation in Autoimmune Thyroid DiseaseThyroid®, 1994
- Hyperthyroid Myopathy and the Response to TreatmentThyroid®, 1991
- Abnormal Left Ventricular Function in HyperthyroidismThe New England Journal of Medicine, 1982
- Noninvasive Evaluation of Cardiac Function in HypothyroidismThe New England Journal of Medicine, 1977