Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats
Open Access
- 24 July 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 51 (10), 1920-1929
- https://doi.org/10.1007/s00125-008-1094-9
Abstract
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) can regulate insulin secretion, insulin action and in vitro hepatocyte glucose release. The aims of this study were to determine whether chemical agents that induce ER stress regulate glucose production in vivo and to identify a physiological setting in which this may be important.This publication has 53 references indexed in Scilit:
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