Role of Polyethylene Glycol Integrity in Specific Receptor Targeting of Carbon Nanotubes to Cancer Cells
- 16 January 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 9 (2), 751-757
- https://doi.org/10.1021/nl8033174
Abstract
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern for certain applications such as drug delivery.This publication has 37 references indexed in Scilit:
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