Predictors of Overweight During Childhood in Offspring of Parents With Type 1 Diabetes
Open Access
- 19 February 2009
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 32 (5), 921-925
- https://doi.org/10.2337/dc08-1943
Abstract
OBJECTIVE: To study which perinatal factors affect the risk of childhood overweight in offspring with a first-degree relative (FDR) with type 1 diabetes and to determine whether maternal diabetes is an independent contributor to overweight risk. RESEARCH DESIGN AND METHODS: Data on a child's weight and height were collected at age 2, 5, and 8 years from 1,214 children participating in the prospective BABYDIAB study. All children had an FDR with type 1 diabetes, including 783 whose mothers had type 1 diabetes. Overweight was defined as BMI percentile ≥90. Data on birth size, breast-feeding, maternal age, and smoking during pregnancy were collected by questionnaires. Risk estimates were calculated by logistic regression analyses. RESULTS: Breastfeeding duration and birth size both contributed significantly to overweight risk at all age intervals. Full breast-feeding >4 months or any breast-feeding >6 months reduced risk of overweight (aged 8 years: odds ratio 0.3 [95% CI 0.2–0.7], P = 0.004; and 0.3 [0.1–0.6], P = 0.001). Large-for-gestational-age status increased risk of overweight (aged 8 years: 2.4 [1.4–4.3], P = 0.002). Importantly, no evidence was found for an independent contribution of maternal type 1 diabetes to childhood overweight. CONCLUSIONS: Our findings indicate that maternal type 1 diabetes is not an independent risk factor for overweight during childhood in offspring of type 1 diabetic mothers but that factors associated with maternal type 1 diabetes, such as short breast-feeding duration and high birth size, predispose children to overweight during childhood.Keywords
This publication has 24 references indexed in Scilit:
- Perinatal predictors of overweight at infancy and preschool childhood: the GENESIS studyInternational Journal of Obesity, 2007
- Expert Committee Recommendations Regarding the Prevention, Assessment, and Treatment of Child and Adolescent Overweight and Obesity: Summary ReportPediatrics, 2007
- Increased Second Trimester Maternal Glucose Levels Are Related to Extremely Large-for-Gestational-Age Infants in Women With Type 1 DiabetesDiabetes Care, 2007
- Breastfeeding habits in families with Type 1 diabetesDiabetic Medicine, 2007
- Breast-Feeding and Risk for Childhood ObesityDiabetes Care, 2006
- Early life risk factors for obesity in childhood: cohort studyBMJ, 2005
- Analyse des Neugeborenenkollektivs der Jahre 1995 - 1997 der Bundesrepublik DeutschlandGeburtshilfe und Frauenheilkunde, 2005
- Insulin Sensitivity in the Offspring of Women With Type 1 and Type 2 DiabetesDiabetes Care, 2004
- Effect of breast milk of diabetic mothers on bodyweight of the offspring in the first year of lifeEuropean Journal of Clinical Nutrition, 2004
- Perzentile für den Body-mass-Index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher StichprobenMonatsschrift Kinderheilkunde, 2001