Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as a Therapeutic Nanoplatform
Top Cited Papers
- 28 December 2015
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 55 (6), 2122-2126
- https://doi.org/10.1002/anie.201510597
Abstract
Molybdenum oxide (MoOx) nanosheets with high near-infrared (NIR) absorbance and pH-dependent oxidative degradation properties were synthesized, functionalized with polyethylene glycol (PEG), and then used as a degradable photothermal agent and drug carrier. The nanosheets, which are relatively stable under acidic pH, could be degraded at physiological pH. Therefore, MoOx-PEG distributed in organs upon intravenous injection would be rapidly degraded and excreted without apparent in vivo toxicity. MoOx-PEG shows efficient accumulation in tumors, the acidic pH of which then leads to longer tumor retention of those nanosheets. Along with the capability of acting as a photothermal agent for effective tumor ablation, MoOx-PEG can load therapeutic molecules with high efficiencies. This concept of inorganic theranostic nanoagent should be relatively stable in tumors to allow imaging and treatment, while being readily degradable in normal organs to enable rapid excretion and avoid long-term retention/toxicity.Funding Information
- National Natural Science Foundation of China (51525203, 51302180, 51222203, 51472049)
- National “973” Program of China (2011CB911002, 2012CB932601)
- Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
- Post-Doctoral Science Foundation of China (2014M561706)
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