P-Phos: A Family of Versatile and Effective Atropisomeric Dipyridylphosphine Ligands in Asymmetric Catalysis
- 22 July 2006
- journal article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 39 (10), 711-720
- https://doi.org/10.1021/ar0680015
Abstract
This Account outlines our efforts in the design and synthesis of a family of highly effective atropisomeric dipyridylphosphine ligands (P-Phos and its variants) and in the development of their widespread applications in transition-metal-catalyzed asymmetric reactions including hydrogenation, hydrosilylation, and C-C bond formation. Desirable attributes, such as air stability, broad substrate scope, fast rates of reaction, excellent enantioselectivities, low catalyst loading, and mild conditions, make the catalyst systems highly attractive and thus may provide excellent opportunities for practical applications.Keywords
This publication has 21 references indexed in Scilit:
- Catalytic Enantioselective Conjugate Reduction of Lactones and LactamsJournal of the American Chemical Society, 2003
- Mechanism of Asymmetric Hydrogenation of α-(Acylamino)acrylic Esters Catalyzed by BINAP−Ruthenium(II) DiacetateJournal of the American Chemical Society, 2002
- Ligand-Accelerated, Copper-Catalyzed Asymmetric Hydrosilylations of Aryl KetonesJournal of the American Chemical Society, 2001
- Principles and Applications of Asymmetric SynthesisPublished by Wiley ,2001
- Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of KetonesAngewandte Chemie-International Edition, 2001
- Catalytic Asymmetric SynthesisPublished by Wiley ,2000
- Synthesis of (−)-(4R,5R)-4,5-bis[di-3′-(2′,6′-dimethoxypyridyl)phosphinomethyl]-2,2-dimethyl-1,3-dioxolane and its application in the Rh-catalyzed asymmetric hydrogenation reactionsTetrahedron: Asymmetry, 1998
- Synthesis of a chiral pyridylphosphine ligand and a comparison of its rhodium complex with the structurally similar arylphosphine rhodium catalysts in the asymmetric hydrogenation of 2-(6′-methoxy-2′-naphthyl)propenoic acidTetrahedron: Asymmetry, 1998
- Enantioselective synthesis of (+)- and (−)-dihydrokawainTetrahedron Letters, 1996
- Asymmetric hydrogenation of .beta.-keto carboxylic esters. A practical, purely chemical access to .beta.-hydroxy esters in high enantiomeric purityJournal of the American Chemical Society, 1987