Tumour heterogeneity and cancer cell plasticity
Top Cited Papers
- 18 September 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 501 (7467), 328-337
- https://doi.org/10.1038/nature12624
Abstract
Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny. However, it remains unclear what fraction of cancers follow the stem-cell model and what clinical behaviours the model explains. Studies using lineage tracing and deep sequencing could have implications for the cancer stem-cell model and may help to determine the extent to which it accounts for therapy resistance and disease progression.Keywords
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