Relevance of biofilms in pediatric tonsillar disease
- 17 April 2011
- journal article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 30 (12), 1503-1509
- https://doi.org/10.1007/s10096-011-1249-3
Abstract
In this investigation, we study the relation between chronic inflammation of the tonsils, clinical features, and the presence of biofilms in the crypts in patients presenting with obstructive hypertrophy and recurrent upper airway pathology. Thirty-six patients who needed to undergo a tonsillectomy for obstructive reasons (aged 1 to 6 years), among which none of them had taken any antibiotics 30 days prior to surgery, were included. Samples were examined with hematoxylin-eosin and Gram staining, fluorescent microscopy, and confocal laser microscopy. The predominance of symptoms were those related to obstructive pathology rather than infection (p < 0.01). All patients had tonsillar hypertrophy (grade III or IV), but an association with adenoids hypertrophy was detected in 66.66% of cases (p < 0.05). 77.28% of tonsils presented biofilms in their crypts, but hypertrophy and tonsillar follicle number were not related to the presence or absence of biofilms. Here, we demonstrated that symptoms like harsh raucous sound, tonsillar and adenoids hypertrophy, apnea, and cervical adenopathies are clearly related to the presence of biofilm in tonsils. Our results allow us to propose that biofilms are involved in the pathogenesis of tonsils and adenoids hypertrophy. The prevention of biofilms formation should be focused in the early stages, attempting to restrain bacterial attachment to the respiratory mucosa.Keywords
This publication has 17 references indexed in Scilit:
- Biofilms in chronic rhinosinusitisCurrent Opinion in Otolaryngology & Head and Neck Surgery, 2010
- Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?Nature Reviews Immunology, 2009
- Effects of Early Environment on Mucosal Immunologic Homeostasis, Subsequent Immune Responses and Disease OutcomeNestle Nutrition Institute workshop series, 2008
- Microparticle transport in the human intestinal M cell modelJournal of Drug Targeting, 2008
- The EPS Matrix: The “House of Biofilm Cells”Journal of Bacteriology, 2007
- Mucosal Remodeling in Chronic RhinosinusitisAmerican Journal of Rhinology, 2007
- Biofilms in Ear, Nose, and Throat Infections: How Important are They?The Laryngoscope, 2007
- The impact of methicillin-resistant Staphylococcus aureus on ENT practiceThe Journal of Laryngology & Otology, 2006
- Antimicrobial Therapy for Children With Adenotonsillar Hypertrophy and Obstructive Sleep Apnea: A Prospective Randomized Trial Comparing Azithromycin vs PlaceboOtolaryngology -- Head and Neck Surgery, 2005
- Forging a Link Between Biofilms and DiseaseScience, 1999